The study aims to investigate the effects of the spatial configuration of traditional Vietnamese houses on the design of apartment buildings in Ho Chi Minh (HCM) City, Vietnam. To achieve the objective, the following approaches were implemented. Firstly, the transformation of the socio-economic structure in HCM City, which is a primary factor affecting the development of apartment buildings was examined. Secondly, the well-known space syntax method for analyzing the spatial structure plan was outlined. Thirdly, a survey of traditional houses and (...) apartment buildings from 1960 to 2010 was conducted. Among the various traditional house styles, the Hue traditional garden house, which has primary effects on the modern housing design in HCM City, was selected as a representative sample to compare with apartment units. Lastly, the space syntax method was employed to analyze the spatial structure of the sample of traditional houses and apartment units. The effects of the Hue traditional house’s spatial configuration on apartment buildings were analyzed. The result shows that the spatial configuration of modern apartment buildings and traditional houses have similar characteristics, including having an adaptable natural environment, and they both reflect Vietnamese culture and society. The findings can be applied when predicting development trends for the unit plans of modern apartments in HCM City, Vietnam. (shrink)